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pandora bracelets Publication bias was evaluated by visual inspection of a funnel plot and Egger’s regression test (significant at P41 if possible publication bias was detected to identify and correct for the asymmetry of funnel plot from publication bias and provide an adjusted summary relative risk based on all the studies, including the estimated missing studies. Stata version 12 (StataCorp LP, College Station, TX, USA) was used for all the statistical analyses.ResultsLiterature searchThrough full text examination of 215 potential publications we identified 26 eligible publications, including 20905 cases of breast cancer and 883585 participants, from 21 independent prospective cohort studies (fig 1). Among these articles, 11 were from the United States,6 8 19 20 21 24 30 32 38 42 43 11 from Europe,17 18 23 25 26 28 31 33 37 44 45 and four from Asia.5 12 27 29 Eleven articles described the association between fish intake and risk of breast cancer,5 12 20 21 28 29 30 31 32 33 42 17 described the association between marine n 3 PUFA intake and risk,5 8 12 17 18 19 20 21 23 24 25 26 27 37 38 43 44 12 reported the association between ALA and risk,8 12 17 18 19 23 24 25 27 37 38 44 and 10 described the association between total n 3 PUFA and risk.5 8 12 18 19 23 24 25 44 45Flow diagram for selection of studies in meta analysis of intake of polyunsaturated fatty acids and risk of breast cancerFig 1 Flow diagram for selection of studies in meta analysis of intake of polyunsaturated fatty acids and risk of breast cancerOpen in new tabStudy characteristicsThe 26 eligible articles were prospective cohort studies with mean follow up ranging from 4.3 to 20 years. pandora bracelets
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